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KMID : 0380020030180060485
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Korean Journal of Biotechnology and Bioengineering
2003 Volume.18 No. 6 p.485 ~ p.489
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Effect of Hepatocyte Growth Factor on the Migration of Human Umbilical Vein Endothelial Cells
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Oh In-Suk
So Sang-Sup
Kim Hwan-Gyu
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Abstract
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Hepatocyte growth factor (HGF) is a mesenchymal-derived cytokine. It exerts a motogenic effect on various target cells, which is displayed either by cell scattering, locomotion, and migration during the wound repair process of cultured cells, or invasiveness through the extracellular matrix, in vitro. Although it is known that HGF influences the motogenic effect of endothelial cells, the precise effects of HGF during migration are still poorly understood. To elucidate the role of HGF in endothelial cell migration, the effect of HGF on endothelial cell migration and MMPs and plasmin production were studied. We found that HGF induces the migration of cultured endothelial cells through increased MMPs and plasmin secretion.
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KEYWORD
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HGF, HUVECs, migration, MMPs, plasmin
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